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Biochemical evidence for Ku-independent backup pathways of NHEJ

Cells of higher eukaryotes process within minutes double strand breaks (DSBs) in their genome using a non-homologous end joining (NHEJ) apparatus that engages DNA-PKcs, Ku, DNA ligase IV, XRCC4 and other as of yet unidentified factors. Although chemical inhibition, or mutation, in any of these facto...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:Nucleic Acids Res
Ngā kaituhi matua: Wang, Huichen, Perrault, Ange Ronel, Takeda, Yoshihiko, Qin, Wei, Wang, Hongyan, Iliakis, George
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Oxford University Press 2003
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC203313/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12954774/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg728
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