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Side-Chain Protonation and Mobility in the Sarcoplasmic Reticulum Ca(2+)-ATPase: Implications for Proton Countertransport and Ca(2+) Release
Protonation of acidic residues in the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA 1a) was studied by multiconformation continuum electrostatic calculations in the Ca(2+)-bound state Ca(2)E1, in the Ca(2+)-free state E2(TG) with bound thapsigargin, and in the E2P (ADP-insensitive phosphoenzyme) analo...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2025671/ https://ncbi.nlm.nih.gov/pubmed/17938423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.109363 |
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