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Side-Chain Protonation and Mobility in the Sarcoplasmic Reticulum Ca(2+)-ATPase: Implications for Proton Countertransport and Ca(2+) Release

Protonation of acidic residues in the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA 1a) was studied by multiconformation continuum electrostatic calculations in the Ca(2+)-bound state Ca(2)E1, in the Ca(2+)-free state E2(TG) with bound thapsigargin, and in the E2P (ADP-insensitive phosphoenzyme) analo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hauser, K., Barth, A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2025671/
https://ncbi.nlm.nih.gov/pubmed/17938423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.109363
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