Mechanism of Islet Amyloid Polypeptide Fibrillation at Lipid Interfaces Studied by Infrared Reflection Absorption Spectroscopy

Islet amyloid polypeptide (IAPP) is a pancreatic hormone and one of a number of proteins that are involved in the formation of amyloid deposits in the islets of Langerhans of type II diabetes mellitus patients. Though IAPP-membrane interactions are known to play a major role in the fibrillation proc...

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Bibliographic Details
Main Authors: Lopes, D. H. J., Meister, A., Gohlke, A., Hauser, A., Blume, A., Winter, R.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2007
Subjects:
Membranes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2025658/
https://ncbi.nlm.nih.gov/pubmed/17660321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.110635
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