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Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.

The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are...

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Sonraí Bibleagrafaíochta
Main Authors: Hall, E. J., Astor, M., Geard, C., Biaglow, J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 1977
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2025538/
https://ncbi.nlm.nih.gov/pubmed/871368
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