The CCR5 receptor acts as an alloantigen in CCR5Δ32 homozygous individuals: Identification of chemokineand HIV-1-blocking human antibodies

The chemokine receptor CCR5 is the major coreceptor for infection by macrophage-tropic R5 HIV-1. A 32-bp deletion in the gene coding for CCR5 (CCR5Δ32) occurs with a frequency of 10% in the Caucasian population and results in a receptor protein that is truncated and not expressed at the cell surface...

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Main Authors: Ditzel, Henrik J., Rosenkilde, Mette M., Garred, Peter, Wang, Meng, Koefoed, Klaus, Pedersen, Court, Burton, Dennis R., Schwartz, Thue W.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC20245/
https://ncbi.nlm.nih.gov/pubmed/9560260
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