Tumor Suppressor Gene Inactivation during Cadmium-Induced Malignant Transformation of Human Prostate Cells Correlates with Overexpression of de Novo DNA Methyltransferase

BACKGROUND: Aberrant DNA methylation is common in carcinogenesis. The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation. OBJEC...

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Détails bibliographiques
Auteurs principaux: Benbrahim-Tallaa, Lamia, Waterland, Robert A., Dill, Anna L., Webber, Mukta M., Waalkes, Michael P.
Format: Artigo
Langue:Inglês
Publié: National Institute of Environmental Health Sciences 2007
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2022656/
https://ncbi.nlm.nih.gov/pubmed/17938735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.10207
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