Tumor Suppressor Gene Inactivation during Cadmium-Induced Malignant Transformation of Human Prostate Cells Correlates with Overexpression of de Novo DNA Methyltransferase

BACKGROUND: Aberrant DNA methylation is common in carcinogenesis. The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation. OBJEC...

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Main Authors: Benbrahim-Tallaa, Lamia, Waterland, Robert A., Dill, Anna L., Webber, Mukta M., Waalkes, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2007
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2022656/
https://ncbi.nlm.nih.gov/pubmed/17938735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.10207
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