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Co-Regulation of p16(INK4a) and Migratory Genes in Culture Conditions that Lead to Premature Senescence in Human Keratinocytes

Cellular stasis, also known as telomere-independent senescence, prevents many epithelial cells from becoming immortalized by telomerase alone. As human keratinocytes age in culture, protein levels of the tumor suppressor p16(INK4a) continue to increase, resulting in growth arrest independent of telo...

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Bibliografski detalji
Glavni autori: Darbro, Benjamin W., Schneider, Galen B., Klingelhutz, Aloysius J.
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2020850/
https://ncbi.nlm.nih.gov/pubmed/16117791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.0022-202X.2005.23844.x
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