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Co-Regulation of p16(INK4a) and Migratory Genes in Culture Conditions that Lead to Premature Senescence in Human Keratinocytes

Cellular stasis, also known as telomere-independent senescence, prevents many epithelial cells from becoming immortalized by telomerase alone. As human keratinocytes age in culture, protein levels of the tumor suppressor p16(INK4a) continue to increase, resulting in growth arrest independent of telo...

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מידע ביבליוגרפי
Main Authors: Darbro, Benjamin W., Schneider, Galen B., Klingelhutz, Aloysius J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2005
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2020850/
https://ncbi.nlm.nih.gov/pubmed/16117791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.0022-202X.2005.23844.x
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