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Co-Regulation of p16(INK4a) and Migratory Genes in Culture Conditions that Lead to Premature Senescence in Human Keratinocytes
Cellular stasis, also known as telomere-independent senescence, prevents many epithelial cells from becoming immortalized by telomerase alone. As human keratinocytes age in culture, protein levels of the tumor suppressor p16(INK4a) continue to increase, resulting in growth arrest independent of telo...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2020850/ https://ncbi.nlm.nih.gov/pubmed/16117791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.0022-202X.2005.23844.x |
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