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Bax directly induces release of cytochrome c from isolated mitochondria

Bax is a pro-apoptotic member of the Bcl-2 protein family that resides in the outer mitochondrial membrane. It is controversial whether Bax promotes cell death directly through its putative function as a channel protein versus indirectly by inhibiting cellular regulators of the cell death proteases...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Jürgensmeier, Juliane M., Xie, Zhihua, Deveraux, Quinn, Ellerby, Lisa, Bredesen, Dale, Reed, John C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1998
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20202/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9560217/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.9.4997
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