Thalidomide induces γ-globin gene expression through increased reactive oxygen species–mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis

Although thalidomide has been shown to improve anemia in some patients with myelodysplastic syndromes and stimulates erythropoietin in patients with multiple myeloma, thalidomide's specific effects on γ-globin gene expression during erythroid differentiation have not been studied. Here, we inve...

Full description

Saved in:
Bibliographic Details
Main Authors: Aerbajinai, Wulin, Zhu, Jianqiong, Gao, Zhigang, Chin, Kyung, Rodgers, Griffin P.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Hematopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2018668/
https://ncbi.nlm.nih.gov/pubmed/17620452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-065201
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items