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Recombinant erythroid Kruppel-like factor fused to GATA1 up-regulates delta- and gamma-globin expression in erythroid cells
The β-hemoglobinopathies sickle cell disease and β-thalassemia are among the most common human genetic disorders worldwide. Hemoglobin A2 (HbA2, α(2)δ(2)) and fetal hemoglobin (HbF, α(2)γ(2)) both inhibit the polymerization of hemoglobin S, which results in erythrocyte sickling. Expression of erythr...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062308/ https://ncbi.nlm.nih.gov/pubmed/21220744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-294751 |
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