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Thalidomide induces γ-globin gene expression through increased reactive oxygen species–mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis

Although thalidomide has been shown to improve anemia in some patients with myelodysplastic syndromes and stimulates erythropoietin in patients with multiple myeloma, thalidomide's specific effects on γ-globin gene expression during erythroid differentiation have not been studied. Here, we inve...

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Autors principals: Aerbajinai, Wulin, Zhu, Jianqiong, Gao, Zhigang, Chin, Kyung, Rodgers, Griffin P.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2018668/
https://ncbi.nlm.nih.gov/pubmed/17620452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-065201
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