The xenobiotic inhibitor profile of cytochrome P4502C8

AIMS: To investigate inhibition of recombinant CYP2C8 by: (i) prototypic CYP isoform selective inhibitors (ii) imidazole/triazole antifungal agents (known inhibitors of CYP), and (iii) certain CYP3A substrates (given the apparent overlapping substrate specificity of CYP2C8 and CYP3A). METHODS: CYP2C...

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Autors principals: Ong, Chin-Eng, Coulter, Sally, Birkett, Donald J, Bhasker, C Ramana, Miners, John O
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2000
Matèries:
Drug Disposition
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015019/
https://ncbi.nlm.nih.gov/pubmed/11136296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00316.x
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