Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine

AIMS: To evaluate whether ketoconazole or cimetidine alter the pharmacokinetics of loratadine, or its major metabolite, desloratadine (DCL), or alter the effects of loratadine or DCL on electrocardiographic repolarization in healthy adult volunteers. METHODS: Two randomized, evaluator-blind, multipl...

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Main Authors: Kosoglou, T, Salfi, M, Lim, J M, Batra, V K, Cayen, M N, Affrime, M B
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2000
Assuntos:
Drug Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015013/
https://ncbi.nlm.nih.gov/pubmed/11136297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00290.x
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