Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine

AIMS: To evaluate whether ketoconazole or cimetidine alter the pharmacokinetics of loratadine, or its major metabolite, desloratadine (DCL), or alter the effects of loratadine or DCL on electrocardiographic repolarization in healthy adult volunteers. METHODS: Two randomized, evaluator-blind, multipl...

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Bibliografiska uppgifter
Huvudupphovsmän: Kosoglou, T, Salfi, M, Lim, J M, Batra, V K, Cayen, M N, Affrime, M B
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 2000
Ämnen:
Drug Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015013/
https://ncbi.nlm.nih.gov/pubmed/11136297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00290.x
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