Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1′-hydroxylation

AIMS: To characterize the effect of an oral contraceptive (OC) containing ethinylestradiol and gestodene on the activity of CYP3A4 in vivo as measured by the 1′-hydroxylation of midazolam. METHODS: In this randomised, double-blind, cross-over trial nine healthy female subjects received either a comb...

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Detalhes bibliográficos
Main Authors: Palovaara, Sanna, Kivistö, Kari T, Tapanainen, Pasi, Manninen, Pekka, Neuvonen, Pertti J, Laine, Kari
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Drug Interaction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015005/
https://ncbi.nlm.nih.gov/pubmed/11012556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00271.x
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