Intravenous diltiazem and CYP3A-mediated metabolism

AIMS: To study whether intravenous diltiazem, a calcium channel blocker commonly prescribed for hypertension and stable angina, is an inhibitor of the CYP3A enzymes by using oral lovastatin, an HMG Co-A reductase inhibitor, as a substrate. METHODS: Ten healthy volunteers were studied in a randomized...

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Autori principali: Masica, Andrew L, Azie, Nkechi E, Brater, D Craig, Hall, Stephen D, Jones, David R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2000
Soggetti:
Short Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014983/
https://ncbi.nlm.nih.gov/pubmed/10971313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00249.x
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