Evaluation of dihydropyrimidine dehydrogenase activity in South-west Asian, Kenyan and Ghanaian populations

AIMS: Dihydropyrimidine dehydrogenase (DPD) reduces endogenous pyrimidines and therapeutic analogues such as the anticancer agent 5-fluorouracil (5FU). Among Caucasian populations DPD activity is highly variable and subject to polymorphic regulation. To evaluate interethnic influence, DPD activity w...

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Bibliographic Details
Main Authors: Morsman, Janine M, Sludden, Julieann, Ameyaw, Margaret-Mary, Githang'a, Jessie, Indalo, Anne, Ofori-Adjei, David, McLeod, Howard L
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2000
Subjects:
Pharmacogenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014976/
https://ncbi.nlm.nih.gov/pubmed/10971312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00242.x
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