Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes

AIMS: To determine the frequencies of 11 CYP2D6 mutant alleles (CYP2D6*2,*3,*4,*5,*8,*10,*11,*12,*14,*17 and *18), and their relation to the metabolic capacity of CYP2D6 in Japanese subjects. METHODS: One hundred and sixty-two unrelated healthy Japanese subjects were genotyped with the polymerase ch...

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Main Authors: Kubota, T, Yamaura, Y, Ohkawa, N, Hara, H, Chiba, K
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
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Main Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014971/
https://ncbi.nlm.nih.gov/pubmed/10886115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00209.x
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