Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes

AIMS: To study the influence of CYP2D6*10 on the formation of p-hydroxymexiletine (PHM) and hydroxymethylmexiletine (HMM) using microsomes from human liver of known genotypes. METHODS: Microsomes from human livers of genotype CYP2D6*1/*1 (n = 5), *1/*10 (n = 6) and *10/*10 (n = 6) were used in this...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Senda, C, Yamaura, Y, Kobayashi, K, Fujii, H, Minami, H, Sasaki, Y, Igarashi, T, Chiba, K
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014511/
https://ncbi.nlm.nih.gov/pubmed/11453897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01411.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados