Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice

AIMS: To determine the effect of grapefruit juice on omeprazole metabolism in vivo. METHODS: This was a randomized crossover study with a 2 week washout period. Omeprazole (20 mg) was taken orally by 13 healthy volunteers after an overnight fast with either grapefruit juice or water. Serial blood sa...

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Hlavní autoři: Tassaneeyakul, Wichittra, Tassaneeyakul, Wongwiwat, Vannaprasaht, Suda, Yamazoe, Yasushi
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2000
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014902/
https://ncbi.nlm.nih.gov/pubmed/10671908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00122.x
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