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Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice
AIMS: To determine the effect of grapefruit juice on omeprazole metabolism in vivo. METHODS: This was a randomized crossover study with a 2 week washout period. Omeprazole (20 mg) was taken orally by 13 healthy volunteers after an overnight fast with either grapefruit juice or water. Serial blood sa...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Science Inc
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014902/ https://ncbi.nlm.nih.gov/pubmed/10671908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00122.x |
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