Population pharmacokinetics of methadone in opiate users: characterization of time-dependent changes

AIMS: Although methadone is widely used to treat opiate dependence, guidelines for its dosage are poorly defined. There is increasing evidence to suggest that a strategy based on plasma drug monitoring may be useful to detect non-compliance. Therefore, we have developed a population-based pharmacoki...

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Autors principals: Rostami-Hodjegan, Amin, Wolff, Kim, Hay, Alastair W M, Raistrick, Duncan, Calvert, Robert, Tucker, Geoffrey T
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 1999
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014882/
https://ncbi.nlm.nih.gov/pubmed/10383559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00974.x
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