Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373

BACKGROUND AND PURPOSE: The ATP-gated P2X(7) receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti-inflammatory drug discovery. We have recently identified a novel set of cyclic imide compounds that inhibited P2X(7) receptor-mediated dye up...

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Autors principals: Stokes, L, Jiang, L-H, Alcaraz, L, Bent, J, Bowers, K, Fagura, M, Furber, M, Mortimore, M, Lawson, M, Theaker, J, Laurent, C, Braddock, M, Surprenant, A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2006
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014691/
https://ncbi.nlm.nih.gov/pubmed/17031385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706933
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