Electroencephalographic effects and serum concentrations after intranasal and intravenous administration of diazepam to healthy volunteers

AIMS: To evaluate the electroencephalographic (EEG) effects, blood concentrations, vehicle irritation and dose-effect relationships for diazepam administered nasally. METHODS: The study had a cross-over design with eight healthy volunteers (one drop out). It consisted of four legs with four differen...

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Autores principales: Lindhardt, Karsten, Gizurarson, Sveinbjörn, Stefánsson, Sigurjón B, Òlafsson, David R, Bechgaard, Erik
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2001
Materias:
Pharmacokinetics/Pharmacodynamics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014600/
https://ncbi.nlm.nih.gov/pubmed/11736860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01486.x
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