Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers

OBJECTIVE: The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. Comparative agents were diazepam rectal gel, which served as the regulatory reference product; and oral diazepam, a product with decades of clinical use. Tolera...

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Bibliographische Detailangaben
Veröffentlicht in:Epilepsia
Hauptverfasser: Hogan, R. Edward, Gidal, Barry E., Koplowitz, Barry, Koplowitz, Luana P., Lowenthal, Richard E., Carrazana, Enrique
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Full‐length Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154760/
https://ncbi.nlm.nih.gov/pubmed/32065672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.16449
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