Effects of anticancer drugs on the metabolism of the anticancer drug 5,6-dimethylxanthenone-4-acetic (DMXAA) by human liver microsomes

AIMS: To investigate the effects of various anticancer drugs on the major metabolic pathways (glucuronidation and 6-methylhydroxylation) of DMXAA in human liver microsomes. METHODS: The effects of various anticancer drugs at 100 and 500 µm on the formation of DMXAA acyl glucuronide (DMXAA-G) and 6-h...

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Bibliographic Details
Main Authors: Zhou, Shufeng, Chin, Rebecca, Kestell, Philip, Tingle, Malcolm D, Paxton, James W
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
Subjects:
Drug Disposition
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014524/
https://ncbi.nlm.nih.gov/pubmed/11488768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01438.x
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