Carbamazepine is not a substrate for P-glycoprotein

AIMS: To determine whether the anticonvulsant carbamazepine (CBZ), a known CYP3A4 substrate, is also a substrate for the multidrug efflux transporter P-glycoprotein (Pgp). METHODS: The role of Pgp in the transport of CBZ was assessed in three systems: (a) in mdr1a/1b(−/−) and wild-type mice after ad...

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Detalhes bibliográficos
Main Authors: Owen, Andrew, Pirmohamed, Munir, Tettey, Justice N, Morgan, Paul, Chadwick, David, Park, B Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014449/
https://ncbi.nlm.nih.gov/pubmed/11318771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01359.x
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