Relationship between the C(3435)T and G(2677)T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver

AIMS: The aim of the study was to determine whether a correlation exists between MDR1 (ABCB1) gene polymorphisms at positions 3435 (C(3435)T) and 2677 (G(2677)T(A)) and the expression of human hepatic P-glycoprotein (P-gp). METHODS: P-gp protein expression in 26 human livers was assessed by Western...

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Bibliographic Details
Main Authors: Owen, Andrew, Goldring, Chris, Morgan, Paul, Chadwick, David, Park, B Kevin, Pirmohamed, Munir
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2005
Subjects:
Short Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884787/
https://ncbi.nlm.nih.gov/pubmed/15752383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02229.x
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