Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus‐infected patients with chronic liver disease

AIMS: To evaluate the single‐dose and multiple‐dose pharmacokinetics of nelfinavir and its active M8 metabolite in eight HIV‐seropositive patients with liver disease, and to examine the relationship between CYP2C19 activity (genotype and plasma M8/nelfinavir metabolic ratio) and the severity of live...

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Detaylı Bibliyografya
Asıl Yazarlar: Khaliq, Yasmin, Gallicano, Keith, Seguin, Isabelle, Fyke, Kathryn, Carignan, Germain, Bulman, Dennis, Badley, Andrew, Cameron, D William
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2000
Konular:
Pharmacodynamics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014390/
https://ncbi.nlm.nih.gov/pubmed/10930962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00238.x
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