Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus‐infected patients with chronic liver disease

AIMS: To evaluate the single‐dose and multiple‐dose pharmacokinetics of nelfinavir and its active M8 metabolite in eight HIV‐seropositive patients with liver disease, and to examine the relationship between CYP2C19 activity (genotype and plasma M8/nelfinavir metabolic ratio) and the severity of live...

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Detalhes bibliográficos
Main Authors: Khaliq, Yasmin, Gallicano, Keith, Seguin, Isabelle, Fyke, Kathryn, Carignan, Germain, Bulman, Dennis, Badley, Andrew, Cameron, D William
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014390/
https://ncbi.nlm.nih.gov/pubmed/10930962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00238.x
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