The antitussive effect of dextromethorphan in relation to CYP2D6 activity

AIMS: To test the hypothesis that inhibition of cytochrome P450 2D6 (CYP2D6) by quinidine increases the antitussive effect of dextromethorphan (DEX) in an induced cough model. METHODS: Twenty-two healthy extensive metaboliser phenotypes for CYP2D6 were studied according to a double-blind, randomised...

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Detalhes bibliográficos
Main Authors: Abdul Manap, R, Wright, C E, Gregory, A, Rostami-Hodjegan, A, Meller, S T, Kelm, G R, Lennard, M S, Tucker, G T, Morice, A H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014340/
https://ncbi.nlm.nih.gov/pubmed/10510150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00029.x
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