Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition

AIMS: To define the relative antitussive effect of dextromethorphan (DEX) and its primary metabolite dextrorphan (DOR) after administration of DEX. METHODS: Data were analysed from a double-blind, randomized cross-over study in which 22 subjects received the following oral treatments: (i) placebo; (...

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Détails bibliographiques
Auteurs principaux: Moghadamnia, A A, Rostami-Hodjegan, A, Abdul-Manap, R, Wright, C E, Morice, A H, Tucker, G T
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2003
Sujets:
Pharmacokinetics and Pharmacodynamics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884341/
https://ncbi.nlm.nih.gov/pubmed/12848776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01853.x
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