Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

AIMS: The genetically polymorphic cytochrome P450 enzyme CYP2C9 metabolizes many important drugs. We studied the frequency of the amino acid variants cysteine(144) (CYP2C9*2) and leucine(359) (CYP2C9*3) in a Turkish population and the correlation between genotype and phenotype using phenytoin as pro...

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Bibliografiske detaljer
Main Authors: Sükrü Aynacioglu, A, Brockmöller, Jürgen, Bauer, Steffen, Sachse, Christoph, Güzelbey, Pinar, Öngen, Zuhal, Nacak, Muradiye, Roots, Ivar
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 1999
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014334/
https://ncbi.nlm.nih.gov/pubmed/10510154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00012.x
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