The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans

AIMS: The purpose of this human intestinal perfusion study was to investigate the effect of ketoconazole on the jejunal permeability and first-pass metabolism of (R)- and (S)-verapamil in humans. METHODS: A regional single-pass perfusion of the jejunum was performed using a Loc-I-Gut® perfusion tube...

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Autores principales: Sandström, Rikard, Knutson, Tina W, Knutson, Lars, Jansson, Britt, Lennernäs, Hans
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 1999
Materias:
Drug Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014302/
https://ncbi.nlm.nih.gov/pubmed/10417494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00999.x
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