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Assays for enhanced activity of low efficacy partial agonists at the D(2) dopamine receptor
BACKGROUND AND PURPOSE: Low efficacy partial agonists at the D(2) dopamine receptor may be useful for treating schizophrenia. In this report we describe a method for assessing the efficacy of these compounds based on stimulation of [(35)S]GTPγS binding. EXPERIMENTAL APPROACH: Agonist efficacy was as...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014272/ https://ncbi.nlm.nih.gov/pubmed/16921389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706866 |
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