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Assays for enhanced activity of low efficacy partial agonists at the D(2) dopamine receptor

BACKGROUND AND PURPOSE: Low efficacy partial agonists at the D(2) dopamine receptor may be useful for treating schizophrenia. In this report we describe a method for assessing the efficacy of these compounds based on stimulation of [(35)S]GTPγS binding. EXPERIMENTAL APPROACH: Agonist efficacy was as...

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書誌詳細
主要な著者: Lin, H, Saisch, S G N, Strange, P G
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014272/
https://ncbi.nlm.nih.gov/pubmed/16921389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706866
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