BML-241 fails to display selective antagonism at the sphingosine-1-phosphate receptor, S1P(3)

BACKGROUND AND PURPOSE: The thiazolidine carboxylic acid, BML-241, has been proposed as a lead compound in development of selective antagonists at the sphingosine-1-phosphate receptor (S1P(3)), based on its inhibition of the rise in intracellular calcium concentrations ([Ca(2+)](i)) in HeLa cells ov...

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Autori principali: Jongsma, M, Hendriks-Balk, M C, Michel, M C, Peters, S L M, Alewijnse, A E
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2006
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014271/
https://ncbi.nlm.nih.gov/pubmed/16940990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706872
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