Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats

BACKGROUND AND PURPOSE: Glucokinase (GK) is the rate-limiting enzyme of hepatic glucose metabolism and acts as a sensor for glucose-stimulated insulin release in β-cells. Here we examine whether the lowering of blood glucose levels in the rat by small molecule glucokinase activators (GKAs) can be pr...

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Detalhes bibliográficos
Main Authors: Coope, G J, Atkinson, A M, Allott, C, McKerrecher, D, Johnstone, C, Pike, K G, Holme, P C, Vertigan, H, Gill, D, Coghlan, M P, Leighton, B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014270/
https://ncbi.nlm.nih.gov/pubmed/16921397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706848
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