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Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes

BACKGROUND AND PURPOSE: Pharmacological activation of glucokinase (GK) lowers blood glucose in animal models and humans, confirming proof of concept for this mechanism. However, recent clinical evidence from chronic studies suggests that the glucose-lowering effects mediated by glucokinase activator...

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Detalhes bibliográficos
Main Authors: Baker, D J, Wilkinson, G P, Atkinson, A M, Jones, H B, Coghlan, M, Charles, A D, Leighton, B
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966745/
https://ncbi.nlm.nih.gov/pubmed/24772484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12504
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