Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism

AIMS: To examine the effect of ticlopidine administration on the activities CYP2C19 and CYP3 A in vivo using omeprazole as a model substrate. METHODS: A single dose of 40 mg omeprazole was administered orally with or without ticlopidine (300 mg daily for 6 days) to six Japanese extensive metaboliser...

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Detalhes bibliográficos
Main Authors: Tateishi, Tomonori, Kumai, Toshio, Watanabe, Minoru, Nakura, Hironori, Tanaka, Masami, Kobayashi, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014235/
https://ncbi.nlm.nih.gov/pubmed/10233213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00914.x
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