Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2

AIMS: To evaluate the effect of the CYP1A2*1C and CYP1A2*1F polymorphisms on the inducibility of CYP1A2 by omeprazole in healthy subjects. METHODS: Mutations of CYP2C19 and CYP1A2 were identified by PCR-RFLP. Omeprazole, 120 mg day(−1), was given to 12 extensive metabolizers (EM) with respect to CYP...

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Detalhes bibliográficos
Main Authors: Han, Xing-Mei, Ouyang, Dong-Sheng, Chen, Xiao-Ping, Shu, Yan, Jiang, Chang-Hong, Tan, Zhi-Rong, Zhou, Hong-Hao
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874453/
https://ncbi.nlm.nih.gov/pubmed/12445035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01686.x
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