Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotypes

AIMS: Omeprazole is mainly metabolized by the polymorphic cytochrome P450 (CYP) 2C19. The inhibitory effect of fluvoxamine, an inhibitor of CYP2C19 as well as CYP1A2, on the metabolism of omeprazole was compared between different genotypes for CYP2C19. METHODS: Eighteen volunteers, of whom six were...

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Detalhes bibliográficos
Main Authors: Yasui-Furukori, Norio, Takahata, Takenori, Nakagami, Taku, Yoshiya, Gen, Inoue, Yoshimasa, Kaneko, Sunao, Tateishi, Tomonori
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884483/
https://ncbi.nlm.nih.gov/pubmed/15025747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02047.x
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