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Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotypes

AIMS: Omeprazole is mainly metabolized by the polymorphic cytochrome P450 (CYP) 2C19. The inhibitory effect of fluvoxamine, an inhibitor of CYP2C19 as well as CYP1A2, on the metabolism of omeprazole was compared between different genotypes for CYP2C19. METHODS: Eighteen volunteers, of whom six were...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yasui-Furukori, Norio, Takahata, Takenori, Nakagami, Taku, Yoshiya, Gen, Inoue, Yoshimasa, Kaneko, Sunao, Tateishi, Tomonori
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884483/
https://ncbi.nlm.nih.gov/pubmed/15025747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02047.x
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