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Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes

AIMS: An in vitro study has suggested that risperidone is a substrate of P-glycoprotein, which is coded by MDR-1 gene. Thus, we studied the effects of major polymorphisms of the MDR-1 gene on plasma drug concentrations. METHODS: Subjects were 85 schizophrenic patients receiving 3 mg twice daily of r...

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Detalhes bibliográficos
Main Authors: Yasui-Furukori, Norio, Mihara, Kazuo, Takahata, Takenori, Suzuki, Akihito, Nakagami, Taku, De Vries, Ronald, Tateishi, Tomonori, Kondo, Tsuyoshi, Kaneko, Sunao
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884506/
https://ncbi.nlm.nih.gov/pubmed/15089809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2003.02061.x
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