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Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes
AIMS: An in vitro study has suggested that risperidone is a substrate of P-glycoprotein, which is coded by MDR-1 gene. Thus, we studied the effects of major polymorphisms of the MDR-1 gene on plasma drug concentrations. METHODS: Subjects were 85 schizophrenic patients receiving 3 mg twice daily of r...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1884506/ https://ncbi.nlm.nih.gov/pubmed/15089809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2003.02061.x |
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