Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations

AIMS: To determine the effects of mibefradil on the metabolism in human liver microsomal preparations of the HMG-CoA reductase inhibitors simvastatin, lovastatin, atorvastatin, cerivastatin and fluvastatin. METHODS: Metabolism of the above five statins (0.5, 5 or 10 μm), as well as of specific CYP3A...

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Detalhes bibliográficos
Main Authors: Prueksaritanont, Thomayant, Ma, Bennett, Tang, Cuyue, Meng, Yuan, Assang, Carol, Lu, Ping, Reider, Paul J, Lin, Jiunn H, Baillie, Thomas A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Drug Metabolism and Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014217/
https://ncbi.nlm.nih.gov/pubmed/10215754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00903.x
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