Cellular uptake of fluvastatin, an inhibitor of HMG-CoA reductase, by rat cultured hepatocytes and human aortic endothelial cells

AIMS: To clarify the mechanism for cellular uptake of fluvastatin (FV) into rat primary cultured hepatocytes and human aortic endothelial cells (HAEC). METHODS: Rat primary cultured hepatocytes and Endocell-AO as normal human aortic endothelial cells were used. Effects of incubation time, concentrat...

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Autors principals: Ohtawa, Masakatsu, Masuda, Naoki, Akasaka, Izumi, Nakashima, Akinori, Ochiai, Keiko, Moriyasu, Matsuko
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 1999
Matèries:
Drug Disposition
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014242/
https://ncbi.nlm.nih.gov/pubmed/10233202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00901.x
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